Table 2: Clinical outcomes of local steroid injection of preventing esophageal stricture after endoscopic resection.

Author, yearDesignSettingSample size
(treated/control)
Follow-upStricture rateMean or median number of EBDAdverse event

Tsujii, 2017 [50]Retrospective studyESD>75%
SENs
28/10Gastroscopy: a few months after ESD43% VS 90% (P=0.012)8 VS 5
(P>0.05)
5 VS 1
Yasuaki, 2017 [52]Retrospective studyESD>2/3but
<100%
SENs
37/37Gastroscopy: every 4 weeks after ESD or receiving complaints of dysphagia18.9% VS 45.9%
(P=0. 016)
0.6±1.5 VS
2.8±4.6
(P<0.01)
None
Furuhashi, 2017 [53]Historical control studyESD≥30mm diameter or ≥3/443/25Not mentionedMultivariate analysis: OR:0.041,95%CI:0.007 to 0.24, p<0.0012.3 VS 10.9None
Xu, 2016 [46]Randomized controlled trialESD≥1/2
SENs
17/23Not mentioned29.4% VS 69.6%
(P=0.02)
0.5 VS 1.3
(P=0.16)
1 VS 0
Yoshiki, 2016 [49]Retrospective studyESD>1/2
SENs
30/15Not mentioned40% VS 60%
(P>0.05)
Not significantly different6 VS 0
Yasuaki, 2016 [47]Retrospective study>2/3but<3/4
ESCC
28/28Gastroscopy: 4 and 8 weeks after the treatment.10.7% VS 35.7%
(P=0.035)
Not mentionedNot mentioned
Takahashi, 2015 [45]Prospective studyESD>75%
ESCC
16/16Not mentioned62.5% VS 87.5%
(P=0. 22)
6.1 VS 12.5
(P=0.04)
1.0% VS 0. 5%
Lee, 2013 [66]Case reportESD 100%
ESCC
1/0Gastroscopy: 2 and 4 weeks and 4 months after ESD. Total follow-up time lasts for 6 months.0%0None
Hanaoka, 2012 [44]Prospective studyESD>75% but<100%
ESCC
30/29Gastroscopy: whenever patients reported dysphagia and 2 months after ESD in patients without dysphagia.10% VS 66%
(P<0.0001)
0 VS 2
(P<0.0001)
2 VS 0
Satoru,2011 [7]RetrospectiveESD
>75%
ESCC
21/20Gastroscopy: assess for stenosis at 1
week, 1 month, 6 months, and 1 year after ETI.
19% VS 75%
(P<0.001)
1.7 VS 6.6
(P<0.001)
None

SENs, superficial esophageal neoplasms; LSI, local steroid injection; DSP, dexamethasone sodium phosphate; TA, triamcinolone acetonide; TTI, topical triamcinolone injection; ESCC, esophageal squamous cell carcinoma.