Canadian Journal of Gastroenterology and Hepatology / 2019 / Article / Tab 2

Review Article

Roles of Steroids in Preventing Esophageal Stricture after Endoscopic Resection

Table 2

Clinical outcomes of local steroid injection of preventing esophageal stricture after endoscopic resection.

Author, yearDesignSettingSample size
Follow-upStricture rateMean or median number of EBDAdverse event

Tsujii, 2017 [50]Retrospective studyESD>75%
28/10Gastroscopy: a few months after ESD43% VS 90% (P=0.012)8 VS 5
5 VS 1
Yasuaki, 2017 [52]Retrospective studyESD>2/3but
37/37Gastroscopy: every 4 weeks after ESD or receiving complaints of dysphagia18.9% VS 45.9%
(P=0. 016)
0.6±1.5 VS
Furuhashi, 2017 [53]Historical control studyESD≥30mm diameter or ≥3/443/25Not mentionedMultivariate analysis: OR:0.041,95%CI:0.007 to 0.24, p<0.0012.3 VS 10.9None
Xu, 2016 [46]Randomized controlled trialESD≥1/2
17/23Not mentioned29.4% VS 69.6%
0.5 VS 1.3
1 VS 0
Yoshiki, 2016 [49]Retrospective studyESD>1/2
30/15Not mentioned40% VS 60%
Not significantly different6 VS 0
Yasuaki, 2016 [47]Retrospective study>2/3but<3/4
28/28Gastroscopy: 4 and 8 weeks after the treatment.10.7% VS 35.7%
Not mentionedNot mentioned
Takahashi, 2015 [45]Prospective studyESD>75%
16/16Not mentioned62.5% VS 87.5%
(P=0. 22)
6.1 VS 12.5
1.0% VS 0. 5%
Lee, 2013 [66]Case reportESD 100%
1/0Gastroscopy: 2 and 4 weeks and 4 months after ESD. Total follow-up time lasts for 6 months.0%0None
Hanaoka, 2012 [44]Prospective studyESD>75% but<100%
30/29Gastroscopy: whenever patients reported dysphagia and 2 months after ESD in patients without dysphagia.10% VS 66%
0 VS 2
2 VS 0
Satoru,2011 [7]RetrospectiveESD
21/20Gastroscopy: assess for stenosis at 1
week, 1 month, 6 months, and 1 year after ETI.
19% VS 75%
1.7 VS 6.6

SENs, superficial esophageal neoplasms; LSI, local steroid injection; DSP, dexamethasone sodium phosphate; TA, triamcinolone acetonide; TTI, topical triamcinolone injection; ESCC, esophageal squamous cell carcinoma.

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