Figure 3: Basal values of lactate dehydrogenase, bile flow, and portal perfusion pressure in healthy, fibrotic, and cirrhotic livers. To induce liver fibrosis, bile duct ligation (BDL) was performed in male SD rats, and to induce liver cirrhosis, animals received thioacetamide (TAA) administered via drinking water. Healthy, fibrotic, and cirrhotic livers were perfused for 30 min. Lactate dehydrogenase (LDH; (a)) was measured in the perfusate, bile was collected to determine the bile flow (b), and the portal perfusion pressure (c) was monitored continuously. All data are expressed as the mean ± SEM. Significant values are specified as p<0.01 (fibrotic/cirrhotic liver compared to healthy liver) and <0.01 (cirrhotic liver compared with fibrotic liver).