Univariable Cox regression analyses for overall graft loss according to recipient etiology of liver disease (HCV negative versus HCV positive).
HCV positive
HCV negative
HR
(95% CI)
P
HR
(95% CI)
P
RECIPIENT
Age (years)
0.988
0.951-1.026
0.517
0.998
0.973-1.024
0.892
Gender (female vs male)
1.794
0.954-3.376
0.070
1.052
0.518-2.135
0.888
MELD score
0.993
0.928-1.063
0.845
1.050
0.993-1.110
0.089
BMI (kg/m2)
1.065
0.967-1.173
0.204
1.001
0.929-1.079
0.979
HCC (yes vs no)
1.139
0.616-2.103
0.678
1.338
0.734-2.439
0.342
DONOR
Age (years)
1.009
0.993-1.026
0.284
1.014
0.996-1.032
0.119
Gender (female vs male)
0.983
0.530-1.821
0.955
1.326
0.729-2.413
0.355
BMI (kg/m2)
1.034
0.919-1.162
0.580
0.954
0.869-1.046
0.314
Cause of death (non trauma vs trauma)
1.014
0.544-1.891
0.965
0.867
0.456-1.650
0.663
ALT (IU/L)
1.000
0.995-1.005
0.948
0.998
0.992-1.004
0.590
AST (IU/L)
0.996
0.990-1.002
0.148
0.999
0.993-1.005
0.797
Sodium (mEq/L)
1.008
0.979-1.038
0.594
0.995
0.964-1.027
0.742
Hemoglobin (gr/dL)
0.993
0.868-1.137
0.923
1.049
0.916-1.201
0.491
PaO2 (mmHg)
1.000
0.996-1.004
0.872
0.999
0.995-1.002
0.557
Anti-HBc status (pos vs neg)
1.424
0.344-5.902
0.626
3.190
1.565-6.501
0.001
Norepinephrine (yes vs no)
1.512
0.813-2.811
0.191
0.588
0.315-1.0.97
0.095
ICU stay (days)
1.121
1.022-1.229
0.015
0.555
0.954-1.091
0.555
GRAFT
Sd-MaS categorical, n (%):
0%
1-15%
0.939
0.453-1.948
0.866
1.284
0.622-2.647
0.499
>15%
0.581
0.239-1.415
0.232
3.146
1.525-6.489
0.002
Sd-MaS, continuous variable (% of hepatocytes)
0.983
0.958-1.010
0.212
1.036
1.018-1.055
<0.001
Ld-MaS categorical, n (%):
0% (reference)
1-15%
0.841
0.445-1.586
0.592
0.694
0.360-1.337
0.275
>15%
0.650
0.194-2.177
0.484
1.430
0.654-3.129
0.371
Ld-MaS, continuous variable (% of hepatocytes)
0.983
0.944-1.024
0.406
1.016
0.992-1.040
0.193
Cold ischemia time (minutes)
1.007
1.003-1.010
<0.001
1.001
0.998-1.005
0.364
Warm ischemia time (minutes)
1.015
1.003-1.027
0.017
0.997
0.982-1.012
0.718
IRI score, categorical§ (severe vs mild/moderate)
2.932
1.399-6.145
0.004
0.961
0.365-2.527
0.935
IPGF (yes vs no)
3.340
1.694-6.584
<0.001
2.152
1.100-4.212
0.025
EAD (yes vs no)
1.839
1.004-3.371
0.049
2.346
1.252-4.396
0.008
Transplant year
0.954
0.854-1.067
0.411
0.900
0.816-0.993
0.036
MELD, model for end-stage liver disease score; HCC, hepatocellular carcinoma; BMI, body mass index; PaO2, partial pressure of oxygen in arterial blood; ICU, intensive care unit; Sd-MaS, small droplet macrovesicular steatosis; Ld-MaS, large droplet macrovesicular steatosis; IRI, histological ischemia/reperfusion injury; IPGF, initial poor graft function; EAD, early allograft dysfunction. §Available in only 55 and 79 recipients with HCV positive and negative liver disease, respectively.
