Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma

Figure 3

Five-year overall survival (OS) curves of PCNA-positive or –negative HCC patients with positive or negative expression of p53, and p53 Ser15-P by Kaplan-Meier Curve. (a, b) OS graphs of the PCNA-negative individuals. (a) OS graph of PCNA-negative and p53-positive and -negative individuals. Black line is p53 positive, and red line is p53 negative. (b) OS graph of PCNA-negative and p53 Ser15-P–positive and –negative individuals. Black line is p53 Ser15-P–positive and red line is p53 Ser15-P–negative. (c, d) OS graphs of PCNA-positive population. (c) OS graph of the PCNA-positive and p53-positive and -negative individuals. Black line is p53 positive, and red line is p53 negative. (d) OS graph of the PCNA-positive and p53 Ser15-P–positive and –negative individuals. Black line is p53 Ser15-P–positive, and red line is p53 serine 15-P negative. P, P value from log rank tests.

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