Treatment Effect of a Vascular-Disrupting Agent Dynamically Monitored by DWI: An Animal Experimental Study

Table 2

The average ADC values of the entire tumor and the solid component of the tumor in two groups (mean ± SD) mm²/s.

Time	Entire tumor		P Value	Solid component of the tumor		P value
	M410 group	Control group		M410 group	Control group
Baseline	1 440.52 ± 180.34	1 409.34 ± 330.79	0.759	1 275.88 ± 236.35	1 266.62 ± 290.70	0.927
4 h	1 338.39 ± 171.49	1 380.28 ± 95.27	0.467	1 212.66 ± 225.05	1 200.69 ± 204.76	0.888
d 1	1 020.61 ± 138.18	1 377.79 ± 467.27	0.032	1 000.45 ± 168.00	1 193.97 ± 219.06	0.04^∗
d 4	1 581.98 ± 190.98	1 360.69 ± 103.18	0.012	1 369.76 ± 230.76	1 140.58 ± 183.17	0.045^∗
d 7	1 621.26 ± 224.87	1 600.43 ± 220.75	0.875	1 284.89 ± 321.94	1 054.57 ± 209.61	0.173
d 14	1 680.36 ± 80.74	1 855.25 ± 158.95	0.097	1 218.34 ± 180.30	991.08 ± 163.56	0.111

ADC; apparent diffusion coefficient, value <0.05 is significant.