The Use of Machine Learning to Create a Risk Score to Predict Survival in Patients with Hepatocellular Carcinoma: A TCGA Cohort Analysis

Table 2

Cox regression: DFS and OS.

	Disease-free survival								Overall survival
	Univariate analysis				Multivariate analysis				Univariate analysis				Multivariate analysis
	HR	95% CI		p value	HR	95% CI		p value	HR	95% CI		p value	HR	95% CI		p value
Score				<0.01				<0.01				0.010
0	1 : 00 reference				1 : 00 reference				1 : 00 reference				1 : 00 reference			0.01
1	2.57	1.38	4.80	0.01	3.41	1.76	6.61	<0.01	1.48	0.83	2.62	0.18	1.95	1.03	3.67	<0.05
2	3.91	2.11	7.24	<0.01	5.54	2.87	10.67	<0.01	2.05	1.17	3.60	<0.01	2.46	1.30	4.63	<0.01
3	5.09	2.70	9.58	<0.01	6.36	3.24	12.49	<0.01	2.42	1.34	4.39	<0.01	2.92	1.52	5.62	<0.01
Gender
Female	1 : 00 reference				1 : 00 reference				1 : 00 reference				1 : 00 reference
Male	1.13	0.79	1.61	0.51	1.81	1.21	2.70	<0.01	0.81	0.57	1.15	0.24	1.05	0.69	1.59	0.82
Age, mean STD	1.00	0.98	1.01	0.73	0.99	0.98	1.00	0.15	1.01	1.00	1.03	0.07	1.00	0.99	1.02	0.74
Race				0.12				<0.01				0.09				0.13
White	1 : 00 reference				1 : 00 reference				1 : 00 reference				1 : 00 reference
Black	0.25	0.06	1.02	0.05	0.16	0.04	0.67	0.01	1.31	0.60	2.85	0.50	1.19	0.50	2.81	0.69
Asian	0.76	0.54	1.07	0.11	0.49	0.32	0.74	0.01	0.66	0.45	0.97	0.04	0.67	0.42	1.06	0.09
Unknown/other	0.99	0.36	2.70	0.98	0.63	0.22	1.79	0.39	1.34	0.54	3.32	0.53	1.75	0.69	4.44	0.24
Stage				0.95				0.85				<0.01				<0.01
1	1 : 00 reference				1 : 00 reference				1 : 00 reference				1 : 00 reference
2	1.03	0.68	1.55	0.89	1.03	0.67	1.59	0.89	1.15	0.73	1.83	0.55	1.10	0.68	1.79	0.70
3	1.14	0.74	1.74	0.56	1.22	0.78	1.90	0.39	2.00	1.30	3.07	<0.01	2.08	1.32	3.28	<0.01
4	1.13	0.28	4.63	0.87	0.97	0.23	4.16	0.97	1.67	0.40	6.91	0.48	2.04	0.48	8.61	0.33
Histologic grade				0.53				0.12				0.43				0.67
1	1 : 00 reference				1 : 00 reference				1 : 00 reference				1 : 00 reference
2	1.47	0.84	2.58	0.17	1.97	1.09	3.55	0.03	1.07	0.63	1.81	0.80	1.19	0.68	2.09	0.54
3	1.27	0.71	2.26	0.43	1.47	0.80	2.71	0.22	0.94	0.54	1.63	0.81	1.05	0.59	1.88	0.87
4	1.13	0.44	2.93	0.79	1.46	0.50	4.28	0.49	0.34	0.08	1.49	0.15	0.53	0.12	2.41	0.41