Systemic Inflammatory Response Syndrome in Patients Hospitalized for Acute Decompensation of Cirrhosis

Table 3

Factors associated with the presence of infection among patients with SIRS.

	SIRS without infection (n = 87)	SIRS with infection (n = 145)
Age (years), mean ± SD	53.5 ± 11.9	55.0 ± 13.7	0.803
Male gender (%)	66.7	64.1	0.696
Diabetes (%)	35.1	39.4	0.563
Beta-blockers (%)	38.4	36.6	0.791
Complication at admission (%)
Ascites	43.7	73.1	<0.001
Hepatic encephalopathy	43.7	57.2	0.045
Gastrointestinal bleeding	57.5	19.3	<0.001
Laboratory data
Sodium (mEq/L), mean ± SD	135.9 ± 29.2	132.9 ± 6.5	0.007
Albumin (g/dL), mean ± SD	2.5 ± 0.6	2.2 ± 0.6	<0.001
INR, median	1.4	1.5	<0.001
Total bilirubin (mg/dL), median	1.6	3.0	0.001
Creatinine (mg/dL), median	1.0	1.3	0.003
Leukocyte count (x10^9), median	6.07	8.10	0.008
CRP (mg/L), median	5.6	14.1	0.005
MELD score, mean ± SD	15.6 ± 6.4	20.2 ± 8.2	<0.001
ACLF (%)	20.7	42.0	0.001
Child-Pugh classification			<0.001
A	11.9	3.5	0.014
B	54.8	35.2	0.004
C	33.3	61.3	<0.001
MAP (mmHg), mean ± SD	87.3 ± 13.9	85.2 ± 15.7	0.304

SIRS = systemic inflammatory response syndrome; SD = standard deviation; INR = international normalised ratio; CRP = C-reactive protein; MELD = Model for End-Stage Liver Disease; ACFL = acute-on-chronic liver failure; MAP = mean arterial pressure.