Transient Elastography in Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease: A Systemic Review and Meta-Analysis

Table 2

Summary diagnostic accuracy parameter estimates and their 95% confidence intervals.

Subgroup		Sensitivity (95% CI)	Specificity (95% CI)	Positive LR (95% CI)	Negative LR (95% CI)	DOR (95% CI)	AUC
F2–F4
BMI ≥28 kg/m^2	21	0.74 [0.69–0.78]	0.78 [0.73–0.83]	3.42 [2.80–4.18]	0.33 [0.29–0.39]	10.24 [7.94–13.21]	0.82 [0.79–0.85]
BMI <28 kg/m^2	14	0.80 [0.72–0.86]	0.85 [0.77–0.90]	5.26 [3.56–7.79]	0.24 [0.18–0.32]	22.06 [13.64–35.69]	0.89 [0.86–0.91]
Prospective	37	0.77 [0.73–0.81]	0.82 [0.78–0.86]	4.34 [3.45–5.46]	0.28 [0.23–0.33]	15.65 [11.33–21.60]	0.86 [0.83–0.89]
Retrospective	3	0.74 [0.65–0.81]	0.82 [0.73–0.88]	3.51 [1.94–6.34]	0.31 [0.18–0.54]	14.74 [7.41–29.32]	0.87 [0.83–0.90]
F3–F4
NAFLD	42	0.81 [0.77–0.85]	0.85 [0.82–0.88]	10.09 [2.16–47.13]	0.14 [0.04–0.53]	25.19 [18.15–34.95]	0.90 [0.87–0.92]
ALD	9	0.80 [0.72–0.86]	0.89 [0.85–0.92]	5.53 [4.44–6.88]	0.22 [0.18–0.27]	31.19 [5.23–17.08]	0.92 [0.89–0.94]
BMI ≥28 kg/m^2	25	0.80 [0.73–0.85]	0.84 [0.79–0.88]	5.00 [3.91–6.40]	0.24 [0.18–0.32]	20.57 [14.59–29.00]	0.89 [0.86–0.91]
BMI <28 kg/m^2	23	0.86 [0.83–0.89]	0.86 [0.82–0.90]	6.26 [4.67–8.37]	0.16 [0.13–0.20]	38.28 [25.84–56.70]	0.92 [0.89–0.94]
Prospective	43	0.82 [0.78–0.86]	0.84 [0.81–0.88]	5.30 [4.34–6.48]	0.21 [0.17–0.26]	25.20 [18.68–39.99]	0.90 [0.87–0.93]
Retrospective	8	0.80 [0.72–0.86]	0.89 [0.85–0.92]	5.53 [4.44–6.88]	0.22 [0.18–0.27]	31.19 [5.23–17.08]	0.92 [0.89–0.94]
=F4
NAFLD	25	0.92 [0.86–0.96]	0.87 [0.83–0.90]	7.18 [5.44–9.47]	0.09 [0.05–0.17]	78.59 [39.17–157.70]	0.95 [0.93–0.97]
ALD	9	0.92 [0.84–0.96]	0.84 [0.76–0.89]	5.64 [3.83–8.30]	0.10 [0.05–0.20]	57.52 [26.27–125.92]	0.94 [0.92–0.96]
BMI ≥28 kg/m^2	12	0.88 [0.78–0.94]	0.85 [0.80–0.89]	5.91 [4.51–7.75]	0.14 [0.07–0.26]	43.04 [23.05–80.35]	0.92 [0.90–0.94]
BMI <28 kg/m^2	17	0.92 [0.86–0.95]	0.88 [0.82–0.92]	7.60 [4.97–11.61]	0.09 [0.06–0.16]	80.28 [38.22–168.63]	0.95 [0.93–0.97]
Prospective	29	0.92 [0.86–0.95]	0.87 [0.83–0.90]	6.90 [5.36–8.88]	0.10 [0.06–0.16]	71.57 [39.82–128.65]	0.95 [0.93–0.96]
Retrospective	5	0.91 [0.85–0.95]	0.83 [0.770.87]	5.29 [3.90–7.17]	0.10 [0.06–0.19]	51.00 [24.71–105.24]	0.94 [0.92–0.96]

LR: likelihood ratio, DOR: diagnostic odds ratio, AUC: area under the curve, and CI: confidence interval.