LncRNA PVT1 Promotes Cell Proliferation, Invasion, and Migration and Inhibits Cell Apoptosis by Phosphorylating YAP

Figure 2

Knockdown of PVT1 inhibits tumor cell proliferation and promotes apoptosis of MKN-45 cells in vitro. (a) Transfection efficiency detected by RT-qPCR, showing that si-PVT1-1748 led to more effective inhibition compared to the other siRNAs. (b) The cell proliferation determined by CCK-8 assay, showing that knockdown of PVT1 inhibits tumor cell proliferation. (c) The cell proliferation of different groups analyzed by colony formation assay, showing that knockdown of PVT1 inhibits tumor cell proliferation. (d, e) The cell apoptotic rate of different groups determined by flow cytometry, showing that knockdown of PVT1 promotes tumor cell apoptosis.

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