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Liver Transplantation: Unresolved Problems and New Challenges

Call for Papers

Liver transplantation represents the curative therapy for end-stage liver disease, hepatocellular carcinoma, and acute liver failure. During the last decades, transplant community strongly modified both access criteria and donor requirements making the access wider (e.g., for alcoholic liver disease) and the donor cohort larger (e.g., with use of marginal donors). Also the surgical techniques have been considerably improved and the continuous improvement in the use of immunosuppressant has determined a noteworthy clinical upgrade in the posttransplant management.

However, there are still many open questions. The waitlist mortality remains very high worldwide. Moreover, an evidence-based approach toward transplanted patients regarding drugs, life-style, and screening protocols is not available. The natural consequence is the lack of homogeneity in terms of indications and clinical management of patients in all transplant phases.

We particularly welcome scientists to contribute with original articles, clinical studies, and review articles describing the current state of the art of clinical and surgical issues regarding liver transplantation. This special issue aims to interest both practitioners and researchers in the areas of hepatology, gastroenterology, infectious disease, internal medicine, and general/transplant surgery.

Potential topics include but are not limited to the following:

  • Liver failure versus hepatocellular carcinoma: different indications and outcome
  • MELD(Na) score: nothing better for transplant priority?
  • NASH as emerging indication and noteworthy posttransplant complication
  • Alcohol and liver transplant: a (yet) debated indication
  • Marginal donors: safety and perspectives
  • Early surgical complications after liver transplant
  • Living donor and split liver: which perspectives
  • Retransplantation: indications and outcomes
  • Long-term metabolic complications of liver transplant
  • Evolution of immunosuppressive drugs
  • Specific issues of pediatric liver transplant
  • Gender peculiarities of transplant process

Authors can submit their manuscripts through the Manuscript Tracking System at

Submission DeadlineFriday, 15 June 2018
Publication DateNovember 2018

Papers are published upon acceptance, regardless of the Special Issue publication date.

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