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Canadian Journal of Infectious Diseases
Volume 1, Issue 2, Pages 48-50
Original Article

Modification of Specific Regions of the Human Cytomegalovirus Genome During in Vitro Passage

Claude Hamelin and Michel Dion

Centre de recherche en virologie, Institut Armand-Frappier, Laval-des-Rapides, Quebec, Canada

Received 19 January 1990; Accepted 12 June 1990

Copyright © 1990 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Different regions of the human cytomegalovirus strain AD-169 DNA molecule were tested for stability using cloned Hind III fragments. Results indicate that insertion, deletion and/or rearrangement of nucleotide sequences occur at a relatively high frequency in all parts of the human cytomegalovirus genome during in vitro passage.