Non-Beta-Lactamase-Producing Penicillin-Resistant Enterococcus faecium in a Clinical Setting
Daniel Eymard,1Andre Dascal,1John Hiscott,1Sonia Gioseffini,1Janet Stevenson,1Joseph Portnoy,1and Jack Mendelson1
Received23 Feb 1990
Accepted28 Jul 1990
Abstract
Six clinical isolates of Enterococcus faecium highly resistant to penicillin are reported. These strains did not produce beta-lactamase and no plasmid DNA could be detected. It is postulated that the mechanism of resistance is one or more chromosomally mediated alterations of penicillin-binding proteins.