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Canadian Journal of Infectious Diseases
Volume 1 (1990), Issue 4, Pages 112-116
http://dx.doi.org/10.1155/1990/280467
Original Article

Pediatric RSV Infection During Two Winter Seasons in British Columbia: A Role for Subgroup Analysis in Young Children?

E Wilson,2 C Orvell,3 B Morrison,1 and E Thomas1

1Departments of Pathology, Pediatrics and Epidemiology, Faculty of Medicine, University of British Columbia, Canada
2British Columbia Children’s Hospital, Vancouver, British Columbia, Canada
3Departments of Virology, National Bacteriological Laboratory and Karolinski Institute, Stockholm, Sweden

Received 23 June 1990; Accepted 26 September 1990

Copyright © 1990 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Using a panel of eight monoclonal antibodies directed against the G, F and NP proteins of respiratory syncytial virus, 167 virus isolates from nasopharyngeal washing cultures at British Columbia Children’s Hospital during two consecutive epidemics were subgrouped. Slides made and frozen at the time of virus isolation or prepared from recovered frozen passage material, were assayed by indirect immunofluorescence. Of 85 strains tested in 1987–88, 54 (64%) were subgroup A, and 31 (36%) subgroup B. By contrast, of 82 strains tested in 1988–89 five (6%) were subgroup A and 77 (94%) subgroup B. Review of patient charts did not reveal significant differences in clinical course of patients infected with the two subgroups, but the risk of infection with subgroup A was significantly greater than the risk of subgroup B infection in younger patients.