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Canadian Journal of Infectious Diseases
Volume 1 (1990), Issue 3, Pages 92-96
Case Report

Meningitis Due to Ampicillin-and Chloramphenicol-Resistant Haemophilus influenzae Type B in Canada. Case Report and Review

Amin Kabani,1,2 Ari Joffe,1,2 Gisele Cadrain, and Taj Jadavji1,2

1Department of Pediatrics, Alberta Children’s Hospital, Calgary, Alberta, Canada
2Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

Received 1 June 1990; Accepted 22 July 1990

Copyright © 1990 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The first report of a case of ampicillin- and chloramphenicol-resistant Haemophilus influenzae type b invasive infection in Canada is described in a four-month-old male with meningitis. He was treated with cefotaxime 200 mg/kg/day divided every 6 h and dexamethasone 0.6 mg/kg/day divided every 6 h, eventually recovering after a complicated course. Follow-up at 21 months showed mild to moderate global developmental delay. While chloramphenicol resistance is rare in North America, a case of meningitis initially unresponsive to ampicillin and chloramphenicol must be considered suspect for resistance. Third generation cephalosporins should be used for resistant cases.