Canadian Journal of Infectious Diseases and Medical Microbiology

Canadian Journal of Infectious Diseases and Medical Microbiology / 1992 / Article

Original Article | Open Access

Volume 3 |Article ID 257026 | https://doi.org/10.1155/1992/257026

Kevin R Forward, Patricia DeGagne, Kathryn R Bartlett, Godfrey K Harding, "Comparative Activity of Daptomycin and Teicoplanin against Enterococci Isolated from Blood and Urine", Canadian Journal of Infectious Diseases and Medical Microbiology, vol. 3, Article ID 257026, 6 pages, 1992. https://doi.org/10.1155/1992/257026

Comparative Activity of Daptomycin and Teicoplanin against Enterococci Isolated from Blood and Urine

Received27 Jul 1990
Accepted21 Feb 1991

Abstract

The authors compared the activity of daptomycin with that of ampicillin, penicillin, teicoplanin and vancomycin against 304 strains of Enterococcus species isolated from blood and urine. Daptomycin was as active as penicillin against Enterococcus faecalis: 90% of strains were inhibited by 2 mg/L. Daptomycin was more active than vancomycin (90% minimal inhibitory concentration [MIC90] 2 mg/L; 90% minimal bactericidal concentration [MBC90] 8 mg/L) but was less active than teicoplanin (MIC50 0.25; MBC90 8 mg/L) or ampicillin (MIC90 1 mg/L; MBC90 2 mg/L) against E faecalis. In time-kill studies daptomycin was not more rapidly bactericidal than ampicillin or penicillin but was significantly more rapidly bactericidal than either teicoplanin or vancomycin. In combination with gentamicin, daptomycin has activity similar to that of penicillin, vancomycin and teicoplanin. Daptomycin may be a suitable alternative to penicillin in patients allergic to penicillins or for the treatment of enterococcal infections caused by beta-lactamase-producing enterococci.

Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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