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Canadian Journal of Infectious Diseases
Volume 3, Issue 5, Pages 231-234
Original Article

Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method

Abdul H Chagla,1 John H Hii,1 Daryl J Hoban,1,2 Andrew E Simor,1,2 Santiago Ferro,1 Evelyn Witwicki,1 Ruby Poon,1 and Donald E Low1

1Departments of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
2Health Sciences Centre, University of Manitoba, Winnipeg, Manitoba, Canada

Received 17 May 1991; Accepted 26 August 1991

Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The in vitro activity of cilofungin against 100 Candida species was compared with 5-flucytosine. amphotericin B and ketoconazole by two laboratories independently and in a blinded fashion using a macrotitre dilution broth method in saam-f medium. Cilofungin showed good in vitro activity against Candida albicans. Candida tropicalis and Candida glabrata (90% minimal inhibitory concentration [MIC] 3.2 μg/mL) but was inactive against other Candida species. When testing the susceptibility of cilofungin, 5-flucytosine and amphotericin B at the two centres, approximately 90% of the Candida strains had MICs differing by fourfold or less. However, when testing susceptibility of ketoconazole, only 51% of the Candida strains had MIC differences fourfold or less. MIC susceptibility testing with cilofungin, 5-flucytosine and amphotericin B in saam-f medium is reproducible.