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Canadian Journal of Infectious Diseases
Volume 3, Issue 1, Pages 23-26
Brief Report

Comparative Evaluation of Seven Commercial Tests for Detection of Heterophile Antibody in Infectious Mononucleosis

Martin Skulnick,1 Donald E Low,1,2 Andrew E Simor,1,2 Mohan Patel,1 Pauline George,2 and Robert Chua1

1Department of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
2Department of Virology, Ministry of Health Laboratory Services Branch, Toronto, Ontario, Canada

Received 4 September 1990; Accepted 18 January 1991

Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Detection of heterophile antibodies in infectious mononucleosis is the most rapid and cost-effective method for confirming the clinical diagnosis of the disease. This study compared seven commercial test kits (the Oxoid Infectious Mononucleosis Kit [Oxoid Ltd], Immunoscan Im-Latex [Baxter Travenol], Mono-Latex [Wampole Laboratories], Monospot and Im Screen Test [Ortho Diagnostics], Immunoscan Im-RBC Test [Baxter Travenol], and Infectious Mononucleosis Test [NCS Diagnostics]) to the Davidsohn differential test. All of the kits were shown to be acceptable for use, with specificities and sensitivities greater than 96.5% and 95.5%, respectively.