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Canadian Journal of Infectious Diseases
Volume 3, Issue 1, Pages 33-36
Case Report

Praziquantel Failure in the Treatment of Fasciola hepatica

David Michael Patrick and Judith Isaac-Renton

Divisions of Microbiology and Infectious Diseases, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada

Received 23 June 1990; Accepted 20 November 1990

Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A case of human fascioliasis is presented in which the patient remained symptomatic after treatment with praziquantel and other agents but eventually responded to bithionol. The difficulties in finding an efficacious and tolerable drug therapy for this condition are reviewed with reference to the life cycle and pathogenesis of the parasite. It is concluded that while bithionol remains the current drug of choice, triclabendazole may play a dominant role in the near future.