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Canadian Journal of Infectious Diseases
Volume 4, Issue 3, Pages 145-147
Case Report

Thrombotic Thrombocytopenic Purpura Associated with Pneumococcal Sepsis

Jeffrey R Schriber, John J Freedman, and Joseph M Brandwein

Division of Hematology, St Michael’s Hospital, and, University of Toronto, Toronto, Ontario, Canada

Received 13 March 1992; Accepted 1 September 1992

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The first documented case of thrombotic thrombocytopenic purpura (TTP) associated with pneumococcal septicemia is reported. This association has been previously demonstrated with hemolytic uremic syndrome. The patient presented with recurrent seizures, oliguric renal failure, fever, thrombocytopenia and microangiopathic hemolytic anemia; coagulation studies were normal. Blood and sputum cultures were positive for Streptococcus pneumoniae. The patient responded to therapy with plasmapheresis and antiplatelet agents as well as antibiotics. Coincident infection should be searched for in all cases of TTP.