Abstract
Mycobacierium avium complex (MAC) infeclion is a common complication of the advanced stages of human immunodeficiency virus (HIV) infection causing both morbidity and premature mortality. While it is acknowledged thal MAC infection requires treatment with a combination of antimycobacterial drugs. the optimal regimen has not been defined. A Canadian Multicentre MAC Treatment Trial was proposed in 1990 and finally implemented in late 1992 via the Canadian HIV Trials Network with the assistance of 6 pharmaceutical companies. The specific drug regimens and study design are outlined and the timetable for analysis and completion are also indicated. Collaborative, Canadian, multicentre clinical trials in HIV disease can be successfully implemented.