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Canadian Journal of Infectious Diseases
Volume 5, Suppl B, Pages 10B-13B

Prophylaxis Against Mycobacterium avium Complex Infection in AIDS

DW Cameron

Canadian HN Trials Network - Ontario Region, Ottawa, Ontmio, Canada

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Disseminated Mycobacterium avium complex (MAC) infection in AIDS is increasing in frequency, although it remains under-recognized due to unlocalized clinical manifestations and subtle initial presentation, if not the need for specialized laboratory diagnostic methods. Ultimately, MAC accounts for much of the “wasting syndrome” in the natural history of human immunodeficiency virus disease. Multidrug treatment of MAC in AIDS is problematic. That MAC is preventable has been demonstrated, and how much clinical benefit can be had from successful prophylaxis remains to be evaluated in the face of improved efficacy of both treatment and prophylaxis regimens under investigation.