Canadian Journal of Infectious Diseases and Medical Microbiology

Canadian Journal of Infectious Diseases and Medical Microbiology / 1995 / Article

Review | Open Access

Volume 6 |Article ID 165848 | https://doi.org/10.1155/1995/165848

Lionel A Mandell, Michel G Bergeron, Marie J Gribble, Peter J Jewesson, Donald E Low, Thomas J Marrie, Lindsay E Nicolle, "Sequential Antibiotic Therapy: Effective Cost Management and Patient Care", Canadian Journal of Infectious Diseases and Medical Microbiology, vol. 6, Article ID 165848, 10 pages, 1995. https://doi.org/10.1155/1995/165848

Sequential Antibiotic Therapy: Effective Cost Management and Patient Care

Received17 May 1995
Accepted11 Aug 1995

Abstract

The escalating costs associated with antimicrobial chemotherapy have become of increasing concern to physicians, pharmacists and patients alike. A number of strategies have been developed to address this problem. This article focuses specifically on sequential antibiotic therapy (sat), which is the strategy of converting patients from intravenous to oral medication regardless of whether the same or a different class of drug is used. Advantages of sat include economic benefits, patient benefits and benefits to the health care provider. Potential disadvantages are cost to the consumer and the risk of therapeutic failure. A critical review of the published literature shows that evidence from randomized controlled trials supports the role of sat. However, it is also clear that further studies are necessary to determine the optimal time for intravenous to oral changeover and to identify the variables that may interfere with the use of oral drugs. Procedures necessary for the implementation of a sat program in the hospital setting are also discussed.

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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