Canadian Journal of Infectious Diseases and Medical Microbiology

Canadian Journal of Infectious Diseases and Medical Microbiology / 1997 / Article

Brief Report | Open Access

Volume 8 |Article ID 386268 | https://doi.org/10.1155/1997/386268

RK Chaudhary, E Burres, "Detection of Antibody to Envelope (E2) Antigen of Hepatitis C Virus", Canadian Journal of Infectious Diseases and Medical Microbiology, vol. 8, Article ID 386268, 3 pages, 1997. https://doi.org/10.1155/1997/386268

Detection of Antibody to Envelope (E2) Antigen of Hepatitis C Virus

Received19 Aug 1996
Accepted15 Jan 1997

Abstract

One hundred and four clinical specimens from provincial public health laboratories were tested for antibody to hepatitis C virus (HCV) envelope protein (anti-E2). To evaluate the effect of hypervariability of E2 region on anti-E2 assay, 49 recombinant immunoblot assay (RIBA) 3.0 positive samples were genotyped. All 49 genotyped samples were positive for anti-E2. Eight of 12 (67%) indeterminate, HCV RNA positive samples were anti-E2 reactive. Nine of 30 (30%) indeterminate, HCV RNA negative samples were also positive for anti-E2. Anti-E2 was detected in two of 13 (15%) RIBA-negative and enzyme immunoassays-positive samples. Although small number of samples were tested, the results showed that it may be possible to resolve indeterminate samples with the anti-E2 assay.

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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