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Canadian Journal of Infectious Diseases
Volume 10 (1999), Suppl C, Pages 9C-15C

Recent Progress in Vaccine Development against Leishmania Species Infections

Barbara Papadopoulou, Martin Olivier, and Marc Ouellette

Centre de Recherche en Infectiologie, Université Laval, Ste-Foy, Québec, Canada

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The understanding of the immunobiology of infections caused by the protozoan parasite leishmania is now extensive and has pinpointed the importance of T cell-mediated immunity. Several vaccination strategies using either killed parasites, subunit vaccines, DNA vaccines or live attenuated strains have been used successfully with and without adjuvants to induce cellular immunity and protect against leishmania infections. The most recent progress in leishmania vaccine development is described.