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Canadian Journal of Infectious Diseases and Medical Microbiology
Volume 17, Issue 4, Pages 243-250
Original Articles

Antimicrobial Resistance among Salmonella and Shigella Isolates in Five Canadian Provinces (1997 to 2000)

Leah J Martin,1 James Flint,1 André Ravel,2 Lucie Dutil,2 Kathryn Doré,1 Marie Louie,3 Frances Jamieson,4 and Sam Ratnam5

1Foodborne, Waterborne and Zoonotic Infections Division, Centre for Infectious Disease Prevention and Control, Population and Public Health Branch, Health Canada (now the Public Health Agency of Canada), Guelph, Ontario, Canada
2Laboratory for Foodborne Zoonoses, Population and Public Health Branch, Health Canada (now the Public Health Agency of Canada), Saint-Hyacinthe, Quebec, Canada
3Provincial Laboratory for Public Health (Microbiology) and the University of Calgary, Calgary, Alberta, Canada
4Ontario Ministry of Health and Long-Term Care, Toronto, Ontario, Canada
5Newfoundland Public Health Laboratory, St John’s, Newfoundland, Canada

Received 31 May 2006; Accepted 31 May 2006

Copyright © 2006 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


OBJECTIVE: To describe rates of antimicrobial resistance (AMR) among Salmonella and Shigella isolates reported in five Canadian provinces, focusing on clinically important antimicrobials.

METHODS: The authors retrospectively investigated AMR rates among 6219 Salmonella and 1673 Shigella isolates submitted to provincial public health laboratories in Alberta, Newfoundland and Labrador, Ontario, Prince Edward Island and Saskatchewan from 1997 to 2000; these isolates were estimated to represent 41% of Salmonella cases and 72% of Shigella cases reported by the study provinces.

RESULTS: Among Salmonella isolates, 27% (1704 of 6215) were resistant to ampicillin, 2.2% (135 of 6122) to trimethoprim/sulfamethoxazole, 1.5% (14 of 938) to nalidixic acid, 1.2% (one of 84) to lomafloxacin and 0.08% (five of 6163) to ciprofloxacin. Among Shigella isolates, 70% (1144 of 1643) were resistant to trimethoprim/sulfamethoxazole, 65% (1079 of 1672) to ampicillin, 3.1% (eight of 262) to nalidixic acid, 0.49% (eight of 1636) to ciprofloxacin, 0.14% (one of 700) to ceftriaxone and 0.08% (one of 1292) to ceftazidime.

CONCLUSIONS: Higher rates of resistance to clinically important antimicrobials (including ciprofloxacin) were observed among both Salmonella and Shigella isolates than has previously been reported. Current Canadian data on rates of AMR for these pathogens are required.