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Canadian Journal of Infectious Diseases and Medical Microbiology
Volume 20 (2009), Issue 4, Pages 122-125
Case Report

Disseminated Herpes Simplex Virus Type 1 Primary Infection in a Healthy Individual

Guy Boivin,1,2 Brigitte Malette,3 and Nathalie Goyette1

1Research Center in Infectious Diseases, Centre Hospitalier Universitaire de Québec, Canada
2Laval University, Québec City, Canada
3Microbiology and Immunology departments of Sainte-Justine Hospital and University of Montréal, Montréal, Quebec, Canada

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


BACKGROUND: Primary herpes simplex virus (HSV) infection usually involves one mucosal region.

OBJECTIVE: To describe an unusual disseminated HSV-1 infection involving two mucosal sites in a healthy man.

RESULTS: Primary HSV infection involved oral and genital mucosa and was associated with viremia, hepatitis and rash. Phylogenetic analysis of genital and oral viruses revealed that the patient was infected by a single HSV-1 strain.

CONCLUSION: Use of polymerase chain reaction detection techniques for HSV may identify viremic patients in the absence of obvious immunosuppression.