Canadian Journal of Infectious Diseases and Medical Microbiology

Canadian Journal of Infectious Diseases and Medical Microbiology / 2009 / Article

Case Report | Open Access

Volume 20 |Article ID 719659 | https://doi.org/10.1155/2009/719659

Eleni Galanis, Linda Hoang, Pamela Kibsey, Muhammad Morshed, Peter Phillips, "Clinical Presentation, Diagnosis and Management of Cryptococcus gattii Cases: Lessons Learned from British Columbia", Canadian Journal of Infectious Diseases and Medical Microbiology, vol. 20, Article ID 719659, 6 pages, 2009. https://doi.org/10.1155/2009/719659

Clinical Presentation, Diagnosis and Management of Cryptococcus gattii Cases: Lessons Learned from British Columbia

Received16 Apr 2008
Accepted05 Sep 2008

Abstract

The environmental fungus Cryptococcus gattii emerged on Vancouver Island, British Columbia (BC), in 1999. By the end of 2006, it led to 176 cases and eight deaths – one of the highest burdens of C gattii disease worldwide. The present paper describes three cases, and the BC experience in the diagnosis and management of this infection. All three cases presented with pulmonary findings, including cryptococcomas and infiltrates. One also presented with brain cryptococcomas. Cases were diagnosed by chest and brain imaging, and laboratory evidence including serum or cerebrospinal fluid cryptococcal antigen detection and culture of respiratory or cerebrospinal fluid specimens. Genotyping of fungal isolates confirmed infection with C gattii VGIIa. Pulmonary cases were treated with fluconazole. One patient with central nervous system disease was treated with amphotericin B followed by fluconazole. Although this infection remains rare, clinicians should be aware of it in patients with a compatible clinical presentation who are either living in or returning from a trip to BC.

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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