Prosthetic joint infection due to Mycobacterium abscessus is uncommon and optimal therapy remains poorly defined. Following a two-stage revision, clinical and microbiological cure was achieved in a patient with a M abscessus-infected total hip arthroplasty. A prolonged course of directed antibacterial therapy comprising clarithromycin and cefoxitin coupled with the application of amikacin-impregnated cement likely contributed to the successful outcome.