Table of Contents Author Guidelines Submit a Manuscript
Canadian Journal of Infectious Diseases and Medical Microbiology
Volume 20, Issue 3, Pages e107-e109
Case Report

Pyogenic Ventriculitis Complicating Aggregatibacter aphrophilus Infective Endocarditis: A Case Report and Literature Review

Gordon W Jung,1 Michael D Parkins,2 and Deirdre Church2,3,4

1Faculty of Medicine and Dentistry, University of Calgary, Canada
2Department of Medicine, University of Calgary, Canada
3Department of Pathology and Laboratory Medicine, University of Calgary, Canada
4Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada

Received 30 May 2008; Accepted 7 October 2008

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pyogenic ventriculitis (PV) is an uncommon, but frequently fatal infection that results from inflammation of the ventricular ependymal lining associated with a purulent ventricular system. PV has been rarely reported as a secondary complication of infective endocarditis. Prompt diagnosis and treatment with appropriate culture-directed antibiotics with adequate central nervous system penetration is crucial when managing patients who are suspected of having PV. The present study reports on a fatal case of a previously well 42-year-old alcoholic woman with infective endocarditis caused by Aggregatibacter aphrophilus, with secondary brain abscess and spontaneous rupture into the ventricles causing PV.