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Canadian Journal of Infectious Diseases and Medical Microbiology
Volume 21, Issue 3, Pages 138-140
Case Report

Ceftobiprole: First Reported Experience in Osteomyelitis

A MacDonald1 and G Dow2

1Northumberland Centre for Medical Education and Research, Canada
2Section of Infectious Diseases, The Moncton Hospital, Horizon Health Network – Zone 1, Moncton, New Brunswick, Canada

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 74-year-old man with long-standing diabetes presented with advanced infection of the right forefoot associated with septic arthritis and osteomyelitis involving the second and third metatarsophalangeal joints. Polymicrobial infection, which included methicillin-resistant Staphylococcus aureus, was documented. First-line antibiotic therapy, which included vancomycin, was not tolerated. A durable cure was obtained following a six-week course of intravenous ceftobiprole medocaril combined with local surgery. The present report is the first to administer intravenous ceftobiprole medocaril to a patient with methicillin-resistant S aureus-associated septic arthritis and osteomyelitis.