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Canadian Journal of Infectious Diseases and Medical Microbiology
Volume 21, Issue 1, Pages e20-e22
Original Article

Genetic Detection of Quinolone Resistance in Haemophilus parainfluenzae: Mutations in the Quinolone Resistance-Determining Regions of gyrA and parC

Dennis KS Law,1 Michelle Shuel,1 Sadjia Bekal,2 Elizabeth Bryce,3 and Raymond SW Tsang1

1Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
2Laboratoire de santé publique du Québec, Institut national de santé publique du Québec, Ste-Anne-de-Bellevue, Québec, Canada
3Division of Medical Microbiology and Infection Control, Vancouver General Hospital, Vancouver, British Columbia, Canada

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The quinolone resistance-determining regions of gyrA and parC of both quinolone-sensitive and quinolone-resistant Haemophilus parainfluenzae strains were amplified and sequenced. Similar to Haemophilus influenzae, resistance to quinolones in H parainfluenzae is associated with mutations in the quinolone resistance-determining regions of both gyrA and parC. The present study discusses the importance of this finding.