Original Article | Open Access
Mariangela R Resende, Shahid Husain, Jonathan Gubbay, Lianne Singer, Edward Cole, Eberhard L Renner, Coleman Rotstein, "Low Seroconversion after One Dose of AS03-Adjuvanted H1N1 Pandemic Influenza Vaccine in Solid-Organ Transplant Recipients", Canadian Journal of Infectious Diseases and Medical Microbiology, vol. 24, Article ID 256756, 4 pages, 2013. https://doi.org/10.1155/2013/256756
Low Seroconversion after One Dose of AS03-Adjuvanted H1N1 Pandemic Influenza Vaccine in Solid-Organ Transplant Recipients
BACKGROUND: Immunocompromised individuals are more susceptible to complications produced by influenza infection. As a result, solid-organ transplant (SOT) recipients were targeted as a priority group to receive AS03-adjuvanted H1N1 influenza vaccine during 2009.OBJECTIVE: To evaluate seroconversion after one dose of adjuvanted pandemic influenza H1N1 (pH1N1) vaccine in SOT recipients.METHODS: Adult SOT recipients were enrolled to receive one 3.75 μg dose of adjuvanted pH1N1 vaccine. Serological status was tested using a hemagglutination inhibition assay before and two and four weeks postvaccination.RESULTS: The five SOT recipients (one liver, two kidney and two lung transplants) had a median age of 50 years (range 36 to 53 years), and three were male, who were a median time of three years (range two months to 15 years) post-transplant. All patients were on a double or triple immunosuppressive regimen. The prevaccination pH1N1 titre was 1:10 in four patients and 1:40 in one patient. Seroprotection was observed only in one patient, with a rise in titre from 1:40 at baseline to 1:320 at both two and four weeks after vaccination. This lung transplant recipient had documented previous infection with pH1N1.CONCLUSION: Results of the present small study call into question whether one dose of adjuvanted pH1N1 vaccine can provide seroprotection in SOT recipients.
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