Canadian Journal of Infectious Diseases and Medical Microbiology

Canadian Journal of Infectious Diseases and Medical Microbiology / 2013 / Article

Case Report | Open Access

Volume 24 |Article ID 427910 | https://doi.org/10.1155/2013/427910

Wilson W Chan, Divya Virmani, Dylan R Pillai, "Artemisinin Combination Therapy Can Result in Clinical Failure If Oral Therapy Is Not Directly Observed", Canadian Journal of Infectious Diseases and Medical Microbiology, vol. 24, Article ID 427910, 2 pages, 2013. https://doi.org/10.1155/2013/427910

Artemisinin Combination Therapy Can Result in Clinical Failure If Oral Therapy Is Not Directly Observed

Abstract

Intravenous artesunate therapy is the first-line therapy for severe malaria, and is highly efficacious when used in combination with an oral partner drug such as doxycycline or atovaquone-proguanil. However, treatment failure occurs routinely with artesunate monotherapy due to the very short half-life of this drug. In North America, experience with artesunate is limited. With the pressure to discharge patients early, administration of the essential oral partner drug is often left to the discretion of the patient. Thus, treatment failure may be commonplace if nonadherence is a factor, as was observed in the case described in the present report.

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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