Canadian Journal of Infectious Diseases and Medical Microbiology

Canadian Journal of Infectious Diseases and Medical Microbiology / 2013 / Article

Review | Open Access

Volume 24 |Article ID 982759 | https://doi.org/10.1155/2013/982759

Cécile Tremblay, Isabelle Hardy, Richard Lalonde, Benoit Trottier, Irina Tsarevsky, Louis-Philippe Vézina, Michel Roger, Mark Wainberg, Jean-Guy Baril, "HIV-1 Tropism Testing and Clinical Management of CCR5 Antagonists: Quebec Review and Recommendations", Canadian Journal of Infectious Diseases and Medical Microbiology, vol. 24, Article ID 982759, 7 pages, 2013. https://doi.org/10.1155/2013/982759

HIV-1 Tropism Testing and Clinical Management of CCR5 Antagonists: Quebec Review and Recommendations

Abstract

HIV-1 tropism assays play a crucial role in determining the response to CCR5 receptor antagonists. Initially, phenotypic tests were used, but limited access to these tests prompted the development of alternative strategies. Recently, genotyping tropism has been validated using a Canadian technology in clinical trials investigating the use of maraviroc in both experienced and treatment-naive patients. The present guidelines review the evidence supporting the use of genotypic assays and provide recommendations regarding tropism testing in daily clinical management.

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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