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Canadian Journal of Infectious Diseases and Medical Microbiology
Volume 2016, Article ID 1321487, 9 pages
Research Article

Evaluation of Risk Factors for Antibiotic Resistance in Patients with Nosocomial Infections Caused by Pseudomonas aeruginosa

1Department of Clinic of Infectious Diseases and Clinical Microbiology, Ankara Training and Research Hospital, Ankara, Turkey
2Department of Microbiology and Clinical Microbiology, Ankara Training and Research Hospital, Ankara, Turkey

Received 19 April 2016; Revised 3 July 2016; Accepted 25 July 2016

Academic Editor: Jorge Garbino

Copyright © 2016 Meliha Cagla Sonmezer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Pseudomonas aeruginosa (P. aeruginosa) is resistant to various antibiotics and can cause serious nosocomial infections with high morbidity and mortality. In this clinical study, we investigated the risk factors in patients who were diagnosed with P. aeruginosa-related nosocomial infection. Methods. A retrospective case control study including patients with P. aeruginosa-related nosocomial infection. Patients who were resistant to any of the six antibiotics (imipenem, meropenem, piperacillin-tazobactam, ciprofloxacin, amikacin, and ceftazidime) constituted the study group. Results. One hundred and twenty isolates were isolated. Various risk factors were detected for each antibiotic in the univariate analysis. In the multivariate analysis, previous cefazolin use was found as an independent risk factor for the development of imipenem resistance (OR = 3.33; CI 95% [1.11–10.0]; = 0.03), whereas previous cerebrovascular attack (OR = 3.57; CI 95% [1.31–9.76]; = 0.01) and previous meropenem use (OR = 4.13; CI 95% [1.21–14.07]; = 0.02) were independent factors for the development of meropenem resistance. For the development of resistance to ciprofloxacin, hospitalization in the neurology intensive care unit (OR = 4.24; CI 95% [1.5–11.98]; = 0.006) and mechanical ventilator application (OR = 11.7; CI 95% [2.24–61.45]; = 0.004) were independent risk factors. Conclusion. The meticulous application of contact measures can decrease the rate of nosocomial infections.