Fosfomycin: A First-Line Oral Therapy for Acute Uncomplicated Cystitis

Table 3

In vitro activity of fosfomycin against facultative Gram-positive bacteria.

Organism	Number tested	Fosfomycin
		MIC50 (g/mL)	MIC90 (g/mL)	Range (g/mL)
Enterococcus faecalis	1862	32	64	0.5–512
Enterococcus faecium	516	32–64	64–128	0.5–128
Enterococcus spp.	137	16–32	64	0.25–>256
Staphylococcus aureus	2213	4	16	0.12–512
Staphylococcus aureus, MRSA	162	4	64	0.5–512
Staphylococcus epidermidis	896	8	128	0.5–256
Staphylococcus saprophyticus	227	64–128	256–>512	≤2–>512
Streptococcus pneumoniae	57	8	16	4–32
Streptococcus pyogenes	50	32	64	2–64
Streptococcus agalactiae	50	32	64	2–64

Data compiled from [12, 32–34, 38, 42].