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Canadian Journal of Infectious Diseases and Medical Microbiology
Volume 2016, Article ID 8192323, 6 pages
Review Article

Mollicutes/HIV Coinfection and the Development of AIDS: Still Far from a Definitive Response

1Department of Pharmaceutical Sciences, University of Blumenau, 89010-350 Blumenau, SC, Brazil
2Biomedical Sciences School, University of Blumenau, 89010-350 Blumenau, SC, Brazil

Received 26 August 2015; Accepted 31 May 2016

Academic Editor: Caroline Gilbert

Copyright © 2016 Caio Mauricio Mendes de Cordova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Mycoplasmas are known to cause various infections in humans, mainly in the respiratory and urogenital tracts. The different species are usually host-specific and cause diseases in well-defined sites. New species have been isolated, including those from HIV-infected persons. Summary. Its in vitro properties, combined with clinical findings, have led to the hypothesis that these microorganisms may act as cofactors of HIV in AIDS development. Even today this point of view is quite polemic among infectious disease specialists and many aspects remain to be clarified, in contrast to what happens, for instance, with HIV/Mycobacterium tuberculosis coinfection. Dozens of papers have been published covering aspects of Mollicutes/HIV coinfection, but they add little to no information about the putative contribution of Mollicutes to the evolution of AIDS. Very few researchers have devoted their efforts to trying to answer this question, which remains open. In this review, we discuss the evidences that may support this statement in the light of current knowledge in the field of mycoplasmology.