Canadian Journal of Infectious Diseases and Medical Microbiology / 2018 / Article / Tab 1

Review Article

Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies

Table 1

Host loci strongly associated with the three common infectious diseases.

DiseasePopulationVariantAnnotationGenome-wide significance ( value)AssociationReferences

HIV-1/AIDSAfrican Americansrs2523608HLA-B57035.6 × 10−10Viral load set point[6]
European ancestryrs2395029HCP5/B57019.7 × 10−26Long-term nonprogression and viral load set point[79]
European ancestryrs9264942HLA-C2.8 × 10−35Long-term nonprogression and viral load set point[7]
European ancestryrs4418214MICA1.4 × 10−34Long-term nonprogression[7]
European ancestryrs3131018PSORS1C34.2 × 10−16Long-term nonprogression
African Americanrs2255221Intergenic3.5 × 10−14Long-term nonprogression
rs2523590HLA-B1.7 × 10−13Long-term nonprogression
rs9262632Intergenic1.0 × 10−8Long-term nonprogression
European ancestryrs9261174ZNRD1, RNF391.8 × 10–8Disease progression[8, 10]
rs11884476PARD3B3.4 × 10–9Disease progression[11]
rs2234358CXCR69.7 × 10–10Long-term nonprogression[12]
MalariaGhanaianrs10900585ATP2B46.1 × 10−9Protective[13]
Ghanaianrs2334880MARVELD33.9 × 10−8Protective[13]
Ghanaianrs8176719ABO2.9 × 10−13Protective[13]
Gambianrs11036238HBB3.7 × 10–11Susceptibility[14]
Gambianrs334HBB4 × 10−14Protective[13, 14]
TuberculosisMoroccanrs17590261AGMO2 × 10−6Age-at-onset of TB[15]
Ghanaian and Gambianrs433142618q11.26.8 × 10−9Susceptibility[16]