Review Article
Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies
Table 1
Host loci strongly associated with the three common infectious diseases.
| | Disease | Population | Variant | Annotation | Genome-wide significance ( value) | Association | References |
| | HIV-1/AIDS | African Americans | rs2523608 | HLA-B∗5703 | 5.6 × 10−10 | Viral load set point | [6] | | European ancestry | rs2395029 | HCP5/B∗5701 | 9.7 × 10−26 | Long-term nonprogression and viral load set point | [7–9] | | European ancestry | rs9264942 | HLA-C | 2.8 × 10−35 | Long-term nonprogression and viral load set point | [7] | | European ancestry | rs4418214 | MICA | 1.4 × 10−34 | Long-term nonprogression | [7] | | European ancestry | rs3131018 | PSORS1C3 | 4.2 × 10−16 | Long-term nonprogression | | African American | rs2255221 | Intergenic | 3.5 × 10−14 | Long-term nonprogression | | rs2523590 | HLA-B | 1.7 × 10−13 | Long-term nonprogression | | rs9262632 | Intergenic | 1.0 × 10−8 | Long-term nonprogression | | European ancestry | rs9261174 | ZNRD1, RNF39 | 1.8 × 10–8 | Disease progression | [8, 10] | | rs11884476 | PARD3B | 3.4 × 10–9 | Disease progression | [11] | | rs2234358 | CXCR6 | 9.7 × 10–10 | Long-term nonprogression | [12] | | Malaria | Ghanaian | rs10900585 | ATP2B4 | 6.1 × 10−9 | Protective | [13] | | Ghanaian | rs2334880 | MARVELD3 | 3.9 × 10−8 | Protective | [13] | | Ghanaian | rs8176719 | ABO | 2.9 × 10−13 | Protective | [13] | | Gambian | rs11036238 | HBB | 3.7 × 10–11 | Susceptibility | [14] | | Gambian | rs334 | HBB | 4 × 10−14 | Protective | [13, 14] | | Tuberculosis | Moroccan | rs17590261 | AGMO | 2 × 10−6 | Age-at-onset of TB | [15] | | Ghanaian and Gambian | rs4331426 | 18q11.2 | 6.8 × 10−9 | Susceptibility | [16] |
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