Xylose Improves Antibiotic Activity of Chloramphenicol and Tetracycline against K. pneumoniae and A. baumannii in a Murine Model of Skin Infection

Figure 1

Xylose potentiates antibiotic activity of efflux-dependent resistant bacteria in a murine model of skin infection. The ability of xylose to increase the susceptibility of clinical A. baumannii and K. pneumomiae strains to tetracycline and chloramphenicol, respectively, was determined in vivo. Bacteria were used to infect skin lesion in mice, prior to treating mice with the antibiotic alone or with a mixture of the antibiotic and xylose. As control, a group of mice was treated with antibiotic and glucose, while another was left untreated. We tested the EDR strain A. baumannii 34702 (a) and the EIR strain A. baumannii 34280 (b) with tetracycline; and the EDR strain K. pneumomiae 28296 (c) and the EIR strain K. pneumomiae 28341 (d) with chloramphenicol. Results are expressed as CFU/mL of homogenized tissue. Experiments were repeated at least 3 times. and according to Student’s t-test.

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