Frequent Recurrences of Genital Herpes Are Associated with Enhanced Systemic HSV-Specific T Cell Response
Table 2
Comparison of immunological parameters in patients with genital herpes and HSV-2 seronegative healthy controls.
Parameter
Group 1 (n = 7)
Group 2 (n = 19)
Controls (n = 12)
value
CD8+CD38+T cells (%; range)
9.3; 8.7–9.9
8.0; 6.9–9.9
9.1; 6.4–1.1
NS
CD8+HLA-DR+T cells (%; range)
2.6; 2.3–1.2
6.3; 5.0–8.1
7.0; 4.0–1.0
NS
CD8+CD38+HLA-DR+T cells (%; range)
1.4; 1.2–5.0
2.3; 1.3–2.7
1.9; 1.1–4.3
NS
IFN-γ+T cells (SFC, HSV-1 stimulation)
65; 29–224
140; 48–249
40; 15–70
<0.01
IFN-γ+T cells (SFC, HSV-2 stimulation)
65; 34–243
180; 56–228
37; 15–98
<0.05
IFN-γ+T cells (SFC, HSV-1 + 2 stimulation)
100; 54–150
125; 54–199
27; 15–65
<0.01
Group 1, patients with low frequency of GH recurrences (<10 recurrences/year); Group 2, patients with high frequency of GH recurrences (>1024 recurrences/year); SFC, spot-forming cells/106 peripheral blood mononuclear cells (mean; range); significant difference from controls; NS, nonsignificant.
