Association of the rs562556 PCSK9 Gene Polymorphism with Reduced Mortality in Severe Malaria among Malian Children
Table 3
Association with symptoms of malaria severity with rs562556 genotypes.
Symptoms
Genotypes
AA
AG/GG
(N = 143)
(N = 64)
n
(%)
n
(%)
Convulsion
73
(51.0)
29
(45.3)
0.4566
Seizures
61
(36.7)
25
(30.5)
0.4446
Prostration
17
(11.9)
8
(12.5)
1.0000
Lethargy
38
(26.6)
13
(20.3)
0.3856
Coma
31
(21.7)
13
(20.3)
0.4612
Resp. symptoms
64
(44.8)
36
(56.3)
0.1351
Respiratory distress
7
(4.9)
3
(4.7)
1.0000
Abdominal pain
16
(11.2)
23
(35.9)
<0.0001
Vomit
69
(48.2)
37
(57.8)
0.2303
Repeated vomit
13
(9.1)
3
(4.7)
0.4002
Diarrhea
42
(30.1)
21
(32.8)
0.6272
No food
16
(11.2)
7
(10.9)
1.0000
Hypoglycemiab
4
(2.8)
0
(0.0)
0.3135
Severe anemiac
22
(14.3)
6
(9.4)
0.2792
Dark urine
11
(8.2)
6
(9.4)
0.7849
Jaundice
8
(5.6)
5
(7.8)
0.5458
Dysurea
6
(4.2)
0
(0.0)
0.1801
Hyperparasitemiad
67
(46.9)
35
(55.6)
0.2960
aP by Fisher’s exact test. Significance was set at 0.05. Significant values are bolded. bGlucose ≤40 mg/dL; chemoglobin ≤5 g/dL; dparasitemia ≥500 000/μL.
