Determination of Voriconazole Plasma Concentration by HPLC Technique and Evaluating Its Association with Clinical Outcome and Adverse Effects in Patients with Invasive Aspergillosis

Table 3

The results of the liver function test according to voriconazole plasma levels.

	VRZ levels
	Subtherapeutic	Therapeutic	Supratherapeutic	value
Mean of total bilirubin (mg/dl)	0.4 ± 0.26	0.95 ± 0.70	1.5 ± 1.13	0.161
Mean of ALT (U/L)	35.33 ± 27.02	84.5 ± 79.08	981 ± 136.13	0.163
Mean of AST (U/L)	22.33 ± 8.39	96.67 ± 88.74	915 ± 123.85	0.151
Mean of ALP (U/L)	228.67 ± 21.82	555 ± 50.05	764.17 ± 87.03	0.210

ALT, alanine transaminase; AST, aspartate aminotransferase; ALP, alkaline phosphatase.