Cytotoxin-Associated Gene A-Positive Helicobacter pylori Promotes Autophagy in Colon Cancer Cells by Inhibiting miR-125b-5p

Figure 1

H. pylori (CagA+) inhibits miR-125b-5p and promotes LC3B-II/LC3B-I and Beclin-1 in colon cancer cells. (a) and (b) represent CagA protein expression was significantly increased after coculture of both the DLD-1 (a) and SW620 (b) colon cancer cell lines with H. pylori (CagA+). (c) and (d) represent that, after coculture with H. pylori (CagA+), miR-125b-5p expression was significantly decreased in both DLD-1 (c) and SW620 (d) cells. (e) and (f) represent the expression of the autophagy-related proteins LC3B-II/LC3B-I and Beclin-1 was significantly higher than that in the control group for both DLD-1 (e) and SW620 (f) cells. .

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