Contrast Media & Molecular Imaging / 2017 / Article / Tab 1

Review Article

Iron Oxide Nanoradiomaterials: Combining Nanoscale Properties with Radioisotopes for Enhanced Molecular Imaging

Table 1

Examples on the combined use of nanomaterials and radioisotopes.

RadioisotopeNanomaterialRadiolabeling methodImaging techniquesApplicationReference

64CuFe3O4-polyaspartic acidChelate approach (DOTA)PET/MRIImaging of tumor integrin expression[26]
64Cuγ-Fe2O3-polyethylene glycolChelate approach (DOTA)PET/MRIBiodistribution studies[27]
64CuFe3O4-dopamine-human serum albuminChelate approach (DOTA)PET/MRIU87MG tumor imaging[28]
64CuFe3O4-dextranChelate approach (DOTA)PET/MRICardiovascular plaque imaging[29]
64CuPoly(lactic-co-glycolic) acid-Fe3O4-polyethylene glycolChelate approach (DOTA)PET/MRITumor imaging in breast cancer models[30]
64CuFe3O4-dextranChelate approach (DOTA)PET/MRIActivated macrophage detection in atherosclerotic plaques[31]
64CuFe3O4-dextranChelate approach (DTCBP)PET/MRILymph node imaging[32]
64Cu-dextranChelate approach (DTPA)PET/MRIActivated macrophage detection in atherosclerotic plaques[33]
64Cu-dextranChelate approach (DTPA)PET/MRIMyeloid cell detection in cardiac allografts[34]
64CuFe3O4-polyethylene glycolChelate approach (NOTA)PET/MRICombined targeted anticancer drug delivery and tumor imaging[35]
64CuMelanin-Fe-polyethylene glycolChelate approach (Melanin)PET/MRIImaging of tumor integrin expression[36]
64CuFe3O4-MoS2-polyethylene glycolChelate–free synthesisPET/MRICombined photothermal therapy and imaging of tumors in breast cancer models[37]
68GaFe3O4-polyethylene glycolChelate-free synthesisPET/MRILymph node imaging[38]
68GaFe3O4-polyethylene glycolChelate approach (NOTA)PET/MRITumor imaging of HT-29 xenografts[39]
68GaFe3O4-polyethylene glycolChelate approach (NOTA)PET/MRILymph node imaging[40]
68Gaγ-Fe2O3-poly(lactic-co-glycolic) acid-b-polyethylene glycolChelate approach (NODA)PET/MRIBiodistribution studies[41]
68GaFe3O4-polyethylene glycolChelate approach (DOTA)PET/MRIPSMA-positive tumor imaging[42]
68Gaγ-Fe2O3-dextranCore-doping approachPET/MRIImaging of tumor integrin expression[23]
18F-dextranClick chemistry (copper-catalyzed azide-alkyne cycloaddition)PET/MRIBiodistribution studies[43]
18FFe3O4-oleylamine branched polyacrylic acidChelate approach (NOTA)PET/MRIBiodistribution studies[44]
18F-dextranClick chemistry (copper-catalyzed azide-alkyne cycloaddition)PET/MRIMacrophage detection in aortic aneurysms[45]
124IFe3O4-polyethylene glycolSurface labelingPET/MRILymph node imaging[46]
124IMnFe2O4-serum albuminSurface labelingPET/MRILymph node imaging[47]
11CFe3O4-COOHSurface labelingPET/MRIBiodistribution studies[48]
89ZrFe3O4-dextranChelate approach (DFO)PET/MRILymph node imaging[49]
69GeFe3O4-polyethylene glycolCore-doping approachSPECT/MRILymph node imaging[50]
Fe3O4-dextranChelate approach (DPA)SPECT/MRIBiodistribution studies[22]
Fe3O4-dopamine-lactobionic acidChelate approach (DTPA)SPECT/MRILiver imaging[51]
Fe3O4-polyethylene glycolChelate approach (pertechnetate)SPECT/MRILymph node imaging[52]
125IFe3O4-dextranChelate approach (CMD)SPECT/MRITumor imaging of breast cancer models[53]