MR Assessment of Acute Pathologic Process after Myocardial Infarction in a Permanent Ligation Mouse Model: Role of Magnetic Nanoparticle-Contrasted MRI

Figure 2

Area-based approach for contrast-enhanced size measurement. Enhanced area (red color) was demarcated using Otsu’s threshold method (b, e, h). The epicardium and endocardium are traced in yellow. The dotted lines in the histogram correspond to the estimated threshold values and green bars represent enhanced pixels in MRI images (c, f, i). The sizes of enhanced area for LGE, MEMRI, and MNP-MRI was 38.7%, 46.3%, and 50.4%, respectively. The horizontal axes represent normalized signal intensity in the MR image.