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Contrast Media & Molecular Imaging
Volume 2017 (2017), Article ID 3179607, 8 pages
Clinical Study

Head-to-Head Comparison of 68Ga-Citrate and 18F-FDG PET/CT for Detection of Infectious Foci in Patients with Staphylococcus aureus Bacteraemia

1Department of Infectious Diseases, Division of Medicine, Turku University Hospital, Turku, Finland
2Turku PET Centre, University of Turku, Turku, Finland
3Faculty of Medicine, University of Turku, Turku, Finland
4Turku PET Centre, Turku University Hospital, Turku, Finland
5Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
6Department of Endocrinology, Division of Medicine, Turku University Hospital, Turku, Finland
7Department of Rheumatology, Division of Medicine, Turku University Hospital, Turku, Finland

Correspondence should be addressed to Anne Roivainen

Received 14 June 2017; Revised 13 August 2017; Accepted 29 August 2017; Published 17 October 2017

Academic Editor: Frank Rösch

Copyright © 2017 Soile P. Salomäki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. This study evaluated the potential of 68Ga-citrate positron emission tomography/computed tomography (PET/CT) for the detection of infectious foci in patients with Staphylococcus aureus bacteraemia by comparing it with 2-[18F]fluoro-2-deoxy--glucose (18F-FDG) PET/CT. Methods. Four patients admitted to hospital due to S. aureus bacteraemia underwent both 18F-FDG and 68Ga-citrate whole-body PET/CT scans to detect infectious foci. Results. The time from hospital admission and the initiation of antibiotic treatment to the first PET/CT was 4–10 days. The time interval between 18F-FDG and 68Ga-citrate PET/CT was 1–4 days. Three patients had vertebral osteomyelitis (spondylodiscitis) and one had osteomyelitis in the toe; these were detected by both 18F-FDG (maximum standardised uptake value [] ) and 68Ga-citrate (  , ). Three patients had soft tissue infectious foci, with more intense 18F-FDG uptake () than 68Ga-citrate uptake (, ). Conclusions. Our small cohort of patients with S. aureus bacteraemia revealed that 68Ga-citrate PET/CT is comparable to 18F-FDG PET/CT for detection of osteomyelitis, whereas 18F-FDG resulted in a higher signal for the detection of soft tissue infectious foci.