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Contrast Media & Molecular Imaging
Volume 2017, Article ID 3981358, 7 pages
https://doi.org/10.1155/2017/3981358
Research Article

Preliminary 19F-MRS Study of Tumor Cell Proliferation with 3′-deoxy-3′-fluorothymidine and Its Metabolite (FLT-MP)

1Division of RI-Convergence Research, Korea Institute of Radiological & Medical Sciences, Seoul, Republic of Korea
2Convergence Institute of Biomedical Engineering and Biomaterials, Seoul National University of Science & Technology, Seoul, Republic of Korea
3Division of Medical Radiation Equipment, Korea Institute of Radiological & Medical Sciences, Seoul, Republic of Korea
4Department of Chemical & Biomolecular Engineering, Seoul National University of Science & Technology, Seoul, Republic of Korea
5Department of Nuclear Medicine, Korea Institute of Radiological & Medical Sciences, Seoul, Republic of Korea

Correspondence should be addressed to Jung Young Kim; rk.er.smarik@mikyj and Ji-Ae Park; rk.er.smarik@krapj

Received 11 May 2017; Accepted 17 July 2017; Published 26 September 2017

Academic Editor: Giancarlo Pascali

Copyright © 2017 In Ok Ko et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1. 19F NMR spectrum of FLT.

Figure S2. 19F NMR spectrum of FLT-MP.

Figure S3. 19F NMR spectra of MCF-7 cells treated with FLT as a function of time. The formation of the FLT-MP signal caused by metabolism of FLT was observed at -174.5 ppm.

Figure S4. 19F MRS of MCF-7 cells treated with FLT.

  1. Supplementary Material