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Contrast Media & Molecular Imaging
Volume 2017 (2017), Article ID 4519653, 6 pages
https://doi.org/10.1155/2017/4519653
Research Article

Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Regional Nodal Metastasis in Nasopharyngeal Carcinoma: Correlation with Nodal Staging

1National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Centre, Shenzhen University, Shenzhen, China
2Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong
3Department of Diagnostic Radiology, The University of Hong Kong, Pokfulam, Hong Kong
4Philips Healthcare, Sheung Wan, Hong Kong
5Mango Solutions, London, UK

Correspondence should be addressed to Pek-Lan Khong; kh.ukh@gnohklp

Received 28 December 2016; Revised 13 March 2017; Accepted 6 April 2017; Published 29 May 2017

Academic Editor: Ziyue Xu

Copyright © 2017 Bingsheng Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To determine if the perfusion parameters by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of regional nodal metastasis are helpful in characterizing nodal status and to understand the relationship with those of primary tumor of nasopharyngeal carcinoma (NPC). Materials and Methods. Newly diagnosed patients imaged between August 2010 and January 2014 and who were found to have enlarged retropharyngeal/cervical lymph nodes suggestive of nodal disease were recruited. DCE-MRI was performed. Three quantitative parameters, , , and , were calculated for the largest node in each patient. Kruskal-Wallis test was used to evaluate the difference in the parameters of the selected nodes of different N stages. Spearman’s correlation was used to evaluate the relationship between the DCE-MRI parameters in nodes and in primary tumors. Results. Twenty-six patients (7 females; 25~67 years old) were enrolled. was significantly different among the patients of N stages (N1, ; N2, ; N3, ), . Median values (range) for N1, N2, and N3 were 0.24 min−1 (0.17~0.26 min−1), 0.29 min−1 (0.17~0.46 min−1), and 0.46 min−1 (0.29~0.70 min−1), respectively. There was no significant correlation between the parameters in nodes and primary tumors. Conclusion. DCE-MRI may play a distinct role in characterizing the metastatic cervical lymph nodes of NPC.