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Contrast Media & Molecular Imaging
Volume 2017 (2017), Article ID 4729547, 16 pages
Review Article

Meta-Analysis of the Correlation between Apparent Diffusion Coefficient and Standardized Uptake Value in Malignant Disease

1Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China
2Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, China
3Molecular Imaging Precision Medicine Collaborative Innovation Center, Shanxi Medical University, Taiyuan, China

Correspondence should be addressed to Bin Zhang and Jianhua Yan

Received 1 July 2016; Accepted 15 January 2017; Published 26 February 2017

Academic Editor: Anne Roivainen

Copyright © 2017 Shengming Deng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objective of this meta-analysis is to explore the correlation between the apparent diffusion coefficient (ADC) on diffusion-weighted MR and the standard uptake value (SUV) of 18F-FDG on PET/CT in patients with cancer. Databases such as PubMed (MEDLINE included), EMBASE, and Cochrane Database of Systematic Review were searched for relevant original articles that explored the correlation between SUV and ADC in English. After applying Fisher’s -to- transformation, correlation coefficient () values were extracted from each study and 95% confidence intervals (CIs) were calculated. Sensitivity and subgroup analyses based on tumor type were performed to investigate the potential heterogeneity. Forty-nine studies were eligible for the meta-analysis, comprising 1927 patients. Pooled for all studies was −0.35 (95% CI: −0.42–0.28) and exhibited a notable heterogeneity ( = 78.4%; < 0.01). In terms of the cancer type subgroup analysis, combined correlation coefficients of ADC/SUV range from −0.12 (lymphoma, = 5) to −0.59 (pancreatic cancer, = 2). We concluded that there is an average negative correlation between ADC and SUV in patients with cancer. Higher correlations were found in the brain tumor, cervix carcinoma, and pancreas cancer. However, a larger, prospective study is warranted to validate these findings in different cancer types.