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Contrast Media & Molecular Imaging
Volume 2017 (2017), Article ID 5369625, 8 pages
Research Article

Associations between 18F-FDG-PET, DWI, and DCE Parameters in Patients with Head and Neck Squamous Cell Carcinoma Depend on Tumor Grading

1Department of Diagnostic and Interventional Radiology, University Hospital of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany
2Department of Nuclear Medicine, University Hospital of Leipzig, Liebigstraße 18, 04103 Leipzig, Germany
3Division of Neuroradiology, University Hospital of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany

Correspondence should be addressed to Alexey Surov

Received 23 June 2017; Revised 31 August 2017; Accepted 12 September 2017; Published 19 October 2017

Academic Editor: Jie Lu

Copyright © 2017 Leonard Leifels et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Our purpose was to analyze associations between positron emission tomography (PET), diffusion weighted imaging (DWI), and dynamic contrast-enhanced (DCE) imaging in patients with head and neck squamous cell carcinoma (HNSCC). The study involved 34 patients (9 women, 25 men, mean age: years). In all patients a simultaneous 18F-FDG-PET/MR was performed. DWI was obtained by using of an axial EPI sequence. Minimal ADC values (), mean ADC values (), and maximal ADC values () were estimated. DCE MRI was performed by using dynamic T1w DCE sequence. The following parameters were estimated: , , and . Spearman’s correlation coefficient was used to analyze associations between investigated parameters. In overall sample, correlated significantly with and , correlated with , and correlated with and . tended to correlate slightly with . In G1/2 tumors, only correlated well with and . In G3 tumors, correlated well with and . showed significant correlations with and . correlated with . was higher in cancers with N2/3 stages. Tumor metabolism, water diffusion, and tumor perfusion have complex relationships in HNSCC. Furthermore, these associations depend on tumor grading. may predict lymphonodal metastasizing.